Approximate fractions of adult doses of antimalarial drugs tor children
| Chloroquine prophyaxis | Mefloquine prophylaxis (5mg/Kg) max 250mg | |||||
| Age (year) | Weight(kg) Fraction |
RCH Melbourne (kg) |
Wt(kg) CDC | Fraction | ||
| < l | < 10 kg | 1/8-1/4 | 5-12: 1/4 per week | < 5 kg | Not Rec | |
| 1 - 4 . | 10 -19 kg | 1/4 | 13-16: 1/3 per week | 10-19 kg | 1/4 per week | |
| 5 - 8 | 20 - 30 kg | 1/2 | 17-24: 1/2 per week | 20 - 30 kg | 1/2 per week | |
| 9 - 15 | 31-45 kg | 3/4 | 25-35: 3/4 per week | 31 - 45 kg | 3/4 per week | |
| > 15 | >45 | Adult | >35: 1 adult per week | > 45 kg | 1 (Adult)/week | |
| Malarone prophylaxis | Doxycycline prophylaxis | ||||
| 11 - 20 kg | 1/4 tab (1 junior tab) daily | Age (year) | Weight(kg) | Fraction | |
| 21 - 30 kg | 1/2 tab (2 junior tab) daily | l - 7 | < 30 kg | Contraindicated | |
| 31 - 40 kg | 3/4 tab (3 junior tab) daily | 8 - 12 | 31-40 kg | 1/2 (50mg) | |
| > 40 kg | 1 tab daily | 12 | > 40 kg | Adult 100mg | |
Chloraquine:- Prophylactic dose 5 mg/kg base/week, up to maximum adult dose of 300 mg base/week.
Mefloquine:- Prophylactic dose 5 mg/kg /week, up to a maximum of 250 mg. (Adult: 250 mg weekly)
Azithromycin:- 250 mg daily (Adult). Less effective than doxycycline, malarone & mefloquine but can be used in children and during pregnancy (also used to treat bacterial dysentry ** WHO )
Primaquine
- not approved for prophylaxis in Australia
Consider if no other alternative: Adult dose 30mg base per day with food -
Children 0.5mg/kg base taken with food.
Tafenoquine (very promising new once weekly primaquine like drug) - not available in Australia
Proguanil:- Prophylactic dose 3 mg/kg daily.(Adult.
200 mg daily)
nb. rarely used by Australian Travel authorities alone
| Proguanil prophylaxis (WHO) | Fansidar prophylaxis | |||||
| Age (year) | Fraction | NHMRC dosage | Age (year) | Weight(kg) | Fraction | |
| < 2 | 50mg/day | < l , 25mg/day | 2-12mth | < l0 | 1/6 | |
| 2-6 . | 1/2 100mg | 1-4 50mg/day . | 1-4 . | I0-19 | 1/3 | |
| 7-10 | 3/4 | 5-8 75mg/day | 5-8 | 20-30 | 1/2 | |
| >10 | Adult | 9-12 100mg/day | 9-15 | 31-45 | 2/3 | |
| >12 150mg/day | >15 | >45 | Adult | |||
Treatment doses (nb. Riamet not approved for use in children under 12 in Australia)
| Riamet (Artemether/Lumefantrine) | Malarone (Atovaquone/Proguanil) | |||
| 10 - 14 kg | 1 adult tab BD for 3 days | 11 - 20 kg | 1 adult tab BD for 3 days | |
| 15 - 24 kg | 2 adult tab BD for 3 days | 21 - 30 kg | 2 adult tab BD for 3 days | |
| 25 - 34 kg | 3 adult tab BD for 3 days | 31 - 40 kg | 3 adult tab BD for 3 days | |
| > 35 kg | 4 adult tab BD for 3 days | > 40 kg | 4 adult tab BD for 3 days | |
Quinine + Fansidar:-
Quinine 600mg (10 mg/kg) every 8 hours for 7 days + 3
tablets Fansidar (Adult)
Quinine + Doxycycline:-
Quinine 600mg (10 mg/kg) every 8 hours for 7 days + 200mg Doxycycline
daily 7 days (Adult)
Mefloquine:- Therapeutic dose: 3
tablets initially, then 2 tabs 6 - 8 hours later
(currently only used if no alternative)